还没做过化疗，EGFR是野生型的病友一定要去做ALK的检测

jzjqian 发表于 2012-7-25 15:45

                               
登录/注册后可看大图

请教，像我这样的，手术22个月了，还能去原手术医院拿到病理作EGFR检查么？

可以，但要有针对性，

请问，肺鳞癌，只做过一次化疗，骨髓抑制严重，后吃特罗凯4个月基本无效，可以参加实验组吗？

不可以了,要没做过任何治疗的,包括化疗和靶向药

Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer.  Print this page  


Sub-category:
% ^2 y1 W1 T* x7 }Molecular Targets
8 D) h6 R) h" E5 z- q1 n# h

9 ?, \" N, @2 _- x$ N# r$ X) ?Category:
Tumor Biology
4 b% i3 G1 G9 e" i& \0 Y& @% J: I

2 A; x; W9 {1 r: ^0 F: n' {Meeting:
2011 ASCO Annual Meeting

( H8 ?1 N6 ~5 k) |) N
Session Type and Session Title:
Poster Discussion Session, Tumor Biology

/ ~6 j+ ]  I6 ?0 z4 `
Abstract No:
10517
/ v4 d2 z  E7 g" @% Y

Citation:
J Clin Oncol 29: 2011 (suppl; abstr 10517)
" d& m6 J0 d) H
5 l9 t% x; M4 ~8 U+ Y
2 k5 F- d4 k8 |3 o0 t: j6 UAuthor(s):
J. Yang, X. Zhang, J. Su, H. Chen, H. Tian, Y. Huang, C. Xu, Y. L. Wu; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangzhou, China; Guangdong Lung Cancer Institute, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China
6 i0 n8 j8 m- m0 I4 h; x' X( t
/ X5 ]- e7 \$ H/ `. z# j3 t8 U( v
  d/ o; k& Z7 [5 r
( D2 s7 p& f; k! U: OAbstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^) here and in the printed Proceedings.

Abstract Disclosures

3 m; u0 t1 P3 Z! Q0 Y$ yAbstract:
! v, F# l  _% m8 |( n' N1 o' H
' h9 z' B) @% D. I! a+ g& M! V
Background: The fusion of the anaplastic lymphoma kinase (ALK) with the echinoderm microtubule-associated protein-like 4 (EML4) and epidermal growth factor receptor (EGFR) mutations are considered mutually exclusive. Advanced non-small cell lung cancer (NSCLC) patients with EML4-ALK did not benefit from EGFR tyrosine kinase inhibitors (TKIs). Methods: Multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) followed by sequencing was performed for EML4-ALK fusion status detection. EGFR and KRAS mutations were determined by direct DNA sequencing. Positive results of EML4-ALK fusion were also confirmed by RACE-coupled PCR sequencing. Results: From April 2010 to January 2011, 412 patients (398 with NSCLC; 14 with SCLC) were tested for mutation status of EGFR, KRAS and EML4-ALK respectively. Frequency of EML4-ALK fusion was 10.6% (42/398) in NSCLC patients. No patients with SCLC were found to have positive EML4-ALK fusion. Frequency of concomitant EGFR and EML4-ALK gene mutations was 1.0% (4/398) in NSCLC patients, and their variants of EML4-ALK gene mutations were Variant 1 (3 patients) and Variant 6 (1 patient); being never smokers, all of them were diagnosed with advanced (3 with stage †W and 1 with stage IIIB) adenocarcinoma harbouring wild type KRAS. Two female stage †W patients with double gene mutations (1 with L858R and Variant 1; 1 with exon19 deletion and Variant 6) received first-line gefitinib which is one kind of EGFR TKIs and achieved partial response. Conclusions: Though being rare events, NSCLC patients harbouring concomitant EGFR mutation and EML4-ALK gene fusion are sensitive to first-line EGFR TKIs. Whether they could also benefit from ALK inhibition after failure to EGFR TKIs warranted further investigation.
1 W% [( f( s4 c- K) g" o2 m
" a  U9 r- k2 z, y8 w' \1 ~0 E; z
# M5 ^7 }! a! U4 S

由吴一龙教授牵头的A80810029临床试验上周启动，初诊未治疗的晚期肺腺癌患者检测到ALK阳性，可参加一线crizotinib 对比力比泰+卡铂的临床研究，药物全部免费，即使分配到力比泰组，疾病进展之后可免费获得crizotinib.

没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

boeun 发表于 2012-11-18 16:37

8 i1 Q$ I6 u/ \( b& b                               
登录/注册后可看大图

- ^: X# k4 L1 j2 k2 E% ?; I没有手术，只化疗过，现吃靶向药，未突变，alk未测，有机会入组吗？

化疗过的没机会了

平安！ 发表于 2012-7-20 11:20

                               
登录/注册后可看大图

3 g; Z. u7 f# b9 E2 s- q( A& [7 v易瑞沙、特罗凯有效的病人基本上可以断定ALK（-）。极其罕见EGFR、ALK同时突变的。
& Y, D$ u  W6 R- w$ v, V. gALK一个指标医院要900多 ...

# p% Y, [1 h  l平安，真的没有希望吗？我弟弟虽然特罗凯有效，但是ＥＧＦＲ是野生型，不是突变啊。有没有必要去检测ＡＬＫ呢？

# a. \9 C, J) T+ S; o现在病情进展，快没招儿了。

好像想加入挺困难的

小地方没条件做啊