发给老马备查:
6 Z t5 i- p! `- K# Y滴水察海(69304838) 15:23:23
% g6 s* b0 j1 i6 |! @+ [老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
# g. U7 S3 ]- O) \/ L, y( z吉非替尼和S-1连用的依据
i- S$ c! U) r' TGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.) J9 b, M4 D5 _. t# i
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达$ ^) E5 R9 G) L
这样是不是推理出,耐药后,可以用S-1和培美了? k5 ~+ E, F. r. h$ n* D5 ^; ]* }( r
结论:# @- e' ^2 |! p. y6 h1 _) S( S" R
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |