发给老马备查:
9 q" H9 }; J# E$ C" V9 T- a滴水察海(69304838) 15:23:23
# b! I6 Y2 ~8 w- s, }0 x老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱8 ~3 Y4 a" P% l7 ~; u
吉非替尼和S-1连用的依据& Q3 ]$ A) y4 z1 @/ B/ U
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.8 y& m+ v \( K6 _" r
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
. a( x: i% c3 S0 A这样是不是推理出,耐药后,可以用S-1和培美了?* h) d6 H: O0 i/ y H- v
结论:3 N9 y8 [, [& Q! Q: y4 t/ e
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |