发给老马备查:
: n, b6 n" C+ A" W; |滴水察海(69304838) 15:23:231 F' l. ~& _ {4 W0 X1 _3 x/ Z" L1 Y
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
+ @) z' q+ _) K9 ~吉非替尼和S-1连用的依据! l) v, a' T$ f
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro./ \7 H# X% N7 T
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
5 d! d% z% {3 c& O0 Z( H这样是不是推理出,耐药后,可以用S-1和培美了?* C+ @0 Z, g3 Z% n" F
结论:
/ s3 x, g3 Q' d6 w如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |