看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies. . }$ e! i! F7 D8 g. p+ z v: i
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) @& O% a# ?: tCombination Feasibility according to preliminary data 8 w: }, D* O) w7 Q, ^
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Bevacizumab + sorafenib Yes, reduced dose 4 q& j1 |" v I
Bevacizumab + sunitinib† No + c, Q* p4 D( r/ m
Bevacizumab + temsirolimus Yes
2 D1 r# i* `. ?9 I5 m8 bBevacizumab + everolimus Yes
: E# ?$ W( ~; p2 H0 W0 TSorafenib + sunitinib ? 4 J% H* T0 i! j6 t& K' t
Sorafenib + temsirolimus Yes, reduced dose ( I+ U% | ?* ^
Sorafenib + everolimus Yes, reduced dose
2 p: h% W' h. TSunitinib + temsirolimus† No 2 J k X4 K! ?! d- H
Sunitinib + everolimus ? 5 [; g; J& V1 P( [9 E. V
Temsirolimus + everolimus ?
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' S! t. H! o8 |- N' j$ R7 L& P†Led to US FDA warning.. S, {9 p( `' d, P6 F$ v. W
?: As yet unattempted combination.
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