穿心莲内酯，穿心莲中分离出一种潜在的癌症治疗剂。

Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract is implicated towards its pharmacological activity. We studied the cellular processes and targets modulated by andrographolide treatment in human cancer and immune cells. Andrographolide treatment inhibited the in vitro proliferation of different tumor cell lines, representing various types of cancers. The compound exerts direct anticancer activity on cancer cells by cell-cycle arrest at G0/G1 phase through induction of cell-cycle inhibitory protein p27 and decreased expression of cyclin-dependent kinase 4 (CDK4). Immunostimulatory activity of andrographolide is evidenced by increased proliferation of lymphocytes and production of interleukin-2. Andrographolide also enhanced the tumor necrosis factor-alpha production and CD marker expression, resulting in increased cytotoxic activity of lymphocytes against cancer cells, which may contribute for its indirect anticancer activity. The in vivo anticancer activity of the compound is further substantiated against B16F0 melanoma syngenic and HT-29 xenograft models. These results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent.

穿心莲植物提取物是已知的具有多种药理活性。穿心莲内酯提取物的主要成分是牵连对其药理活性。我们研究的细胞过程和目标调制的穿心莲内酯在人类癌症和免疫细胞治疗。穿心莲内酯治疗抑制不同肿瘤细胞株的体外增殖，代表不同类型的癌症。化合物发挥直接的抗癌活性，对癌细胞的细胞周期阻滞在G0/G1期的细胞周期抑制蛋白p27诱导和降低细胞周期蛋白依赖性激酶4（CDK4）表达。穿心莲内酯的免疫刺激活性的淋巴细胞增殖和白细胞介素-2生产增加。穿心莲内酯也增强了肿瘤坏死因子-α生产CD标志物的表达，从而在对抗癌细胞的淋巴细胞的细胞毒活性增加，这可能导致其间接的抗癌活性。在体内的化合物的抗癌活性，进一步证实对肿瘤黑色素瘤同系和HT-29移植模型。这些结果表明，穿心莲内酯是一种具有抗癌和免疫调节活动有趣的药效具有被开发作为癌症治疗剂的潜力

这还是2003年发表在美国国立卫生院的提出的，但是十多年过去了，一直没有人后续研究了。

谢谢资料分享！

说说就好了，鸦胆子油说是也能抗癌。